In hypoxic tumor microenvironment, bone marrow-derived mesenchymal stem cells (BMSCs) secreted exosomes that contained miR-193a-3p, miR-210-3p and miR-5100, these exosomes were taken up by neighboring epithelial lung cancer cells, led to STAT3 signaling activation and increased expression of mesenchymal related molecules (75). This evidence concerns the gene STAT3 and neoplasm.