Wnt4, S100A9, MiR-210-3p, miR-361-3p, miR-410-3p, circ-133 were reported to be remarkably elevated in hypoxic CRC exosomes, and can be transferred to normoxic CRC cells, leading to facilitated cell growth and suppressed cell apoptosis, eliciting a protumoral effect, promoting cancer metastasis and enhancing tumor progression. Here, S100A9 is linked to colorectal carcinoma.