It is important to note that, in the retroviral-vector-induced murine model of Notch1-dependent T-ALL, the expansion of CD11b+Gr-1+ myeloid cells was described in non-transduced populations (25, 26), and Notch3 was reported as a transcriptional target of Notch1 in transduced DP T cells from the BM (10). Here, NOTCH1 is linked to acute lymphoblastic leukemia.