Moreover, both Notch1 and Notch3 deregulation seems able to generate MDSCs from human PBMCs, as suggested by our observations on MDSC induction with human T-ALL cell lines, KE-37 and TALL-1, that overexpress in a mutually exclusive way active-Notch1 and active-Notch3, respectively. The gene discussed is NOTCH3; the disease is acute lymphoblastic leukemia.