In vivo mouse experiments further revealed that, in agreement with the in vitro analyses, treatments with P-selectin (rP-sel), Nlrp3 inflammasome (OLT1177 and Z-WEHD-FMK), apoptosis (Z-DEVD-FMK), and ROS (NAC and MitoTEMPO) inhibitors markedly ameliorated ND-induced thrombocytopenia (Figure 7A), and platelet pyroptosis (Figure 7B, except Z-DEVD-FMK) and apoptosis (Figure 7C) levels in C57BL/6J mice. The gene discussed is SELP; the disease is Thrombocytopenia.