A common SNP of BDNF, rs62265, is a missense mutation that has been associated with anxiety, major depression, suicide, and neurodegenerative disease, as has dysregulation of mTOR signaling (Dincheva et al., 2016; Youssef et al., 2018; Bar-Yosef et al., 2019). Here, BDNF is linked to major depressive disorder.