It has been suggested that such cases should no longer be classified as CIDP (11), which may be an additional reason for using the terminology “CIP.” Otherwise, we have identified in nerve samples from a few patients both types of lesions: “internodopathies” and “paranodopathies.” Although the proportion of patients with IgG4 and IgG3 against paranodal junction and node of Ranvier components appears small (probably <5% of the CIDP patients), their detection may be decisive for diagnosis and treatment with drugs such as rituximab. The gene discussed is IGHG3; the disease is chronic inflammatory demyelinating polyradiculoneuropathy.