VKORC1 and atrial fibrillation: For example, in a subgroup analysis of the ENGAGE AF-TIMI 48 (Effective aNticoaGulation with factor xA next GEneration in Atrial Fibrillation-Thrombolysis In Myocardial Infarction study 48) trial, of the 4,833 patients taking warfarin (dosed based on the patient’s clinical profile), 1711 (34%) and 140 (3%) respectively were categorized as sensitive and highly sensitive responders depending on their CYP2C9 and VKORC1 genotypes (Mega et al., 2015).