GSK3B and Nausea and vomiting: Recently, our laboratory has shown that large doses (10 and 20 mg/kg) of the GSK-3β inhibitor, AR-A014418, significantly protects against pilocarpine- and McN-A-343-induced emesis, whereas only a lower dose of the more potent GSK-3αβ inhibitor SB216763 (0.25 mg/kg, i.p.), was required for the suppression of vomiting evoked by these cholinergic agonists (Zhong and Darmani 2020).