Even less is known about the effects of adiponectin on the microvasculature, however we have shown that chronic exposure to either globular adiponectin or AdipoRON, a nonselective adiponectin receptor agonist, restores NO-mediated FID in arterioles from patients diagnosed with CAD (Schulz et al., 2019). The gene discussed is ADIPOQ; the disease is coronary artery disorder.