CAT and coronary artery disorder: The dual mediator phenotype is abolished in CAD vessels treated with both siAdipoR1 and osmotin as L-NAME had no effect on dilation (%MD 88.7 ± 8.4, n = 4, Figure 4B) whereas PEG-catalase significantly reduced vasodilatory capacity compared to vessels with no inhibitor present (%MD 7.6 ± 5.2, n = 4 versus 84.3 ± 2.8, n = 5, respectively).