Therefore, we conducted a systematic review and network meta-analysis to compare the efficacy of different PCSK9 inhibitors with different dosage as an add-on statin therapy in reducing the levels of LDL-C and lipoproteins e.g., ApoB and Lp(a), which are also important causal agents of atherosclerosis, and reducing cardiac events and the safety in adults with hyperlipidemia. The gene discussed is PCSK9; the disease is atherosclerosis.