Additionally, HMGA2 and KLF4 regulation are able to promote PI3K/Akt phosphorylation, resulting in increased drug resistance (Deng et al., 2021), and miR-26a interacts with HMGA2 (Yang et al., 2016) and miR-145 with KLF4 (Cui et al., 2018) to promote DDP-resistance in lung cancer cells. The gene discussed is AKT1; the disease is lung carcinoma.