MiR-18a, miR-19a, miR-21, miR-25-3p, miR-130b and miR-1269b in lung cancer cells (Xiao et al., 2018; Zhang et al., 2018; Xing et al., 2019; Yang W. et al., 2020; Gu et al., 2020; Sun B. et al., 2021; Liang et al., 2021), and miR-21 and miR-106a in gastric cancer cells (Fang et al., 2013; Yang et al., 2013; Zheng et al., 2017) directly regulate PTEN, and reduced miRs levels expression in cancer cells promote PTEN expression, triggering apoptosis and DDP-resistance. Here, PTEN is linked to cancer.