WNT10B and colorectal cancer: Bao et al. (2020) demonstrated EIF5A2 was targeted by miR-9 and was upregulated in lung tumor cells, thus promoting chemoresistance to DDP by increasing EMT process. Also, Wnt10b has been involved in enhanced tumor cell stemness by upregulation of OCT4 and NANOG expression. In colorectal cancer, WNT10b is directly targeted by miR-148a and the reduced miR-148a expression enhances Wnt10b levels to allow drug resistance in cancer therapy (Shi et al., 2019).