A total of 3 mg/kg/day celastrol (OA) significantly increased the HSF1 (Heat Shock Transcription Factor 1)/PGC-1α axis activity and protected against obesity in HFD mice by increasing energy expenditure, including iWAT browning, BAT activation, and mitochondrial gene transcription, while such benefit was abrogated by HSF1 depletion (Ma et al., 2015). The gene discussed is HSF1; the disease is obesity disorder.