Feng and his colleagues demonstrated that the protective property of celastrol on obesity reversed by IL1R1 deficiency, which indicated that IL1R1 is essential for celastrol to reduce food consumption and body weight, alleviate glucose intolerance and insulin tolerance, as well as hepatic steatosis in HFD mice (Feng et al., 2019). Here, IL1R1 is linked to obesity due to melanocortin 4 receptor deficiency.