DNAJB1 and Huntington disease: In fact, the HDJ-2 and HSP70 chaperones were found to co-localize with HTT aggregates in the brain of R6/2 HD transgenic mice expressing the N-terminal truncated fragment of mHTT (Mangiarini et al., 1996), and exogenous expression of chaperons HDJ-1 and HSP70 reduced the amount aggregates formed by mHTT and ameliorated the toxicity in cell models of HD (Jana et al., 2000).