Moreover, peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α), a transcriptional coactivator (Lin et al., 2002, 2005) that works in combination with other transcription factors like PPARγ may play an important role in HD pathogenesis (Cui et al., 2006; Weydt et al., 2006). The gene discussed is PPARG; the disease is Huntington disease.