Alarmins stimulate APCs, and granulysin, which is present at high levels in patients with APS (especially in those who test positive for anti‐PE antibodies), activates PRR‐expressing DCs, which may further enhance granulysin secretion by NKT cells, NK cells, and CTLs, and eventually induce miscarriage via its direct effect on apoptosis. Here, GNLY is linked to autoimmune polyendocrinopathy.