In a previous study, we observed elevated levels of cytotoxic granules and inflammatory cytokines, such as IL‐2 and IL‐12, as well as of perforin and granzyme B, at the implantation site rather than at the systemic level in a murine miscarriage model induced by α‐galactosylceramide (α‐GalCer).40 Here, PRF1 is linked to Miscarriage.