Taking these factors into consideration, Na et al., have developed a pancreatic tumor-targeted nanohybrid vector that combines an ECM-degrading and Wnt/β-catenin signal inhibiting oAd with NTR targeting neurotensin peptide (NT)-conjugated PEG (oAd/DCN/LRP-PEG-NT) [56]. Here, NTSR1 is linked to pancreatic neoplasm.