TRMT6 and urothelial carcinoma: Lastly, we found TRMT6/61A expression is upregulated in urothelial carcinoma of the bladder relative to the normal bladder lining, and this is accompanied by higher m1A levels on tRF-3s and upregulation of tRF-3 targets that are enriched in the unfolded protein response (Figs. 7 and 8).