BCR and chronic myelogenous leukemia, BCR-ABL1 positive: Chronic myeloid leukemia (CML) are hematopoietic malignancies that arise from transformation of hematopoietic stem cells (HSC) driven by chimeric oncoprotein BCR-ABL, a constitutively active tyrosine kinase generating from the t(9;22)(q34;q11) chromosomal translocation [1–3].