Thirteen non-redundant factors were included in the RDA including, six periodontal metrics (shallow or deep periodontal pocket depth, percent of sites bleeding on probing, full-mouth classification of periodontal status using the CDC/AAP periodontitis definition, average whole-mouth pocket depth, average whole-mouth attachment loss, and percent of sites with attachment loss >3), three demographic factors (participant, sex, and age), three metabolic factors (fasting insulin, prediabetes status, and average systolic blood pressure) and one lifestyle factor (tobacco-smoking status). Here, INS is linked to prediabetes syndrome.