PBRM1 and nonpapillary renal cell carcinoma: Based on 512 ccRCC cases in the PanCancer study of TCGA, the most frequently mutated genes in ccRCC are: VHL (41%), PBRM1 (38%), SETD2 (12%), BAP1 (10%), MTOR (8%) and KDM5C (5%)6–8.