Immunoblotting analysis revealed that EIF2α, EIF2Bε, RPL10, and RPS3 (associated with EIF2 signaling) are more abundant in murine esophageal keratinocytes cultured in 0.018 mM calcium whereas GSTP1 and GSTA4 (associated with glutathione-mediated detoxification) are more abundant in murine esophageal keratinocytes undergoing calcium-mediated SCD (Fig. 2d). This evidence concerns the gene GSTP1 and Schnyder corneal dystrophy.