We found that B7-H3.28 and B7-H3.BB CAR-T cells effectively controlled NSCLC cell growth (Fig. 1d, e), and their cytolytic activity was corroborated by IFNγ and IL2 release in the culture supernatant (Fig. 1f, g), and by T cell proliferation in response to B7-H3+ target cells, as assessed by CFSE dilution assay (Supplementary Fig. 1d). This evidence concerns the gene CD276 and non-small cell lung carcinoma.