Of note, in the tumor model in which NSCLC tumor cells are engrafted both in the lung and in the brain, the CCR2b coexpression in B7-H3.CAR-T cells continued to show activity against the tumor in the brain suggesting that CCR2b.B7-H3.CAR-T cells retain enhanced trafficking through the BBB even if the primary tumor is still present in the lung. This evidence concerns the gene CD276 and non-small cell lung carcinoma.