In separate experiments, in which mice were sacrificed at day 8 post CAR-T cell infusion for enumerating CAR-T cells in blood, spleen and tumor, we found that T-cell numbers in blood and spleen were similar in mice treated with B7-H3.28 or CCR2b.B7-H3.28 CAR-T cells, while we observed a significant increase of CAR-T cells in the tumor in mice receiving CCR2b.B7-H3.28 CAR-T cells (Fig. 5e). This evidence concerns the gene CCR2 and neoplasm.