Notably, the list of significant DEGs included ApoE and Trem2 (triggering receptor expressed on myeloid cells 2), the two genes that most increase sporadic AD risk, as well as the minor AD risk genes, Cntnap2 (contactin associated protein 2) and C4b (complement component 4B) (Supplemental Data File 1). This evidence concerns the gene TREM2 and Alzheimer disease.