APP and Alzheimer disease: To assess if the SCDi-mediated changes in MHC-I genes are relevant to other AD mouse models, we compared our WT-D/3xTg-D microglia DEG list with DEG lists from four distinct AD models, including bulk RNA-sequencing data sets from 5xFAD40 or APP-SAA (Xia, GSE158153) microglia and single-cell RNA sequencing from AppNL-G-F KI mice34 or APP/PS136 microglia (Fig. 5j).