Herein, we revealed a novel mechanism by which CXCR7 mediates CRC metastasis and found that exosomal miR-146a-5p and miR-155-5p play an important role in the crosstalk between CXCR7-overexpressing cancer cells and stromal CAFs, forming a feedback loop to facilitate CRC metastasis. This evidence concerns the gene ACKR3 and colorectal carcinoma.