ACKR3 and colorectal carcinoma: The potential function of CAFs in lung metastasis of CRC upon CXCL12/CXCR7 activation was further explored in vivo, and the results showed that the mice developed a larger number of lung nodules when injected with HCT116 cells educated by CM from MRC-5 overexpressing miR-146a-5p and miR-155-5p (Fig. 7E, F).