ACKR3 and colorectal carcinoma: Exosomes from CRC cells overexpressing CXCR7 recapitulated the effects of transfection with miR-146a-5p and miR-155-5p mimics, showing a pronounced increase in the levels of TNF-α and IL-6 as well as elevated TGF-β and CXCL12 to a lesser extent (Fig. 6F).