TP53 and medulloblastoma: Although SIK1 has previously been shown to be a tumor suppressor due to its role in promoting p53-dependent anoikis in breast cancer [28] and mediating tumor-suppressor function of LKB1 in lung cancer [29], the oncogenic role of SIK1 in DSRCT is in line with recent observations that SIK1 is able to promote cell growth in oxygen-glucose deprived mouse neuro-endothelial cells [30] and in down-regulating the p53 apoptosis pathway in medulloblastoma [31].