CD274 and adenocarcinoma: In addition, the ROC curves based on the objective response demonstrate that TMB (AUC = 0.582, 95% CI 0.377–0.787, P = 0.44) and PD-L1 CPS (AUC = 0.529, 95% CI 0.291–0.767, P = 0.82) were not associated with the response to ICI treatment in the dMMR/MSI-H G/GEJ adenocarcinomas (Additional file 1: Fig. S6).