Among the clinicopathological and genomic characteristics, NMP exhibited the strongest negative correlation with DTICs, including CD3+ (P < 0.001), CD4+ (P = 0.065), CD8+ (P = 0.004), and FOXP3+ (P = 0.033) cells in the central tumor area (marked by a red arrow, Fig. 2). This evidence concerns the gene FOXP3 and neoplasm.