In the future, it would be beneficial to assess changes in a broader spectrum of parameters to better understand the clinical potential and mechanisms of action of Delta-5/SA, including: erythema; skin surface pH; skin hardness; skin- and lipid thickness of the epidermis; lipid amounts and types (such as levels of SA in free- and esterified forms, and eicosanoids) from punch biopsies; and inflammatory markers (such as interleukins, tumor necrosis factor). The gene discussed is TNF; the disease is Erythema.