Spearman correlation analysis (Table 4) showed that: a positive correlation (the correlation coefficient was positive) was found between the accumulation of skin AGEs and the risk scores of the four major complications of diabetes (CVD risk score, DPN risk score, DR risk score, and DN risk score), renal function indicators (Cr, CysC, Hcy, ACR, MAU, α-MG, Tf, and U-Ig G), inflammatory indicators (NEUT, NLR, and CRP), and TCSS score. The gene discussed is GAN; the disease is diabetes mellitus.