MAPK8 and neoplasm: These inter-leukin-like cytokines are common JNK target genes that activate the JAK/STAT pathway (Arbouzova and Zeidler, 2006) in regeneration and tumor contexts (Ahmed-de-Prado et al., 2018; Jiang et al., 2009; La Marca and Richardson, 2020; Pastor-Pareja et al., 2008; Santabarbara-Ruiz et al., 2015; Worley et al., 2018; Wu et al., 2010).