In fact, gene set enrichment analysis (GSEA) of RNA-sequencing (RNA-seq) data from isolated MYC-expressing Cdk9-suppressed tumor cells (but not controls) showed reversal of signatures associated with MYC expression and ribosome biogenesis (SI Appendix, Fig. S3E) as was observed in orthotopic models (6, 27). Here, MYC is linked to neoplasm.