However, moderate to severe pathologies were noted in CAGs-rtTA3; TG-Cdk9.421E mice 4 wk after continuous Dox treatment, including acinar atrophy and acinar-to-ductal metaplasia (ADM) in the pancreas, myocarditis in the heart, and gastritis and metaplasia in the stomach (Fig. 2J and SI Appendix, Fig. S1B). This evidence concerns the gene CDK9 and myocarditis.