However, moderate to severe pathologies were noted in CAGs-rtTA3; TG-Cdk9.421E mice 4 wk after continuous Dox treatment, including acinar atrophy and acinar-to-ductal metaplasia (ADM) in the pancreas, myocarditis in the heart, and gastritis and metaplasia in the stomach (Fig. 2J and SI Appendix, Fig. S1B). The gene discussed is CDK9; the disease is gastritis.