Patients with any of these four recessive inborn errors of immunity underlying a complete deficiency of cellular responses to type I IFNs are prone to various viral diseases, with AR STAT1 deficiency underlying the most diverse and severe set of viral diseases, including those caused by live attenuated virus (LAV) vaccines (Gothe et al., 2021; Poyhonen et al., 2019). Here, AR is linked to viral infectious disease.