IL4 and colitis: We have previously shown that C. jejuni isolates from human GBS patients colonize the IL-10−/− mice without inducing colitis but do elicit autoantibody production.20 These responses were associated with decreased Type1/17 cytokine response, but an enhanced Type 2 cytokine response.20 Therefore, we hypothesized that development of autoimmunity in C57BL/6 IL-10−/− mice infected with a C. jejuni GBS patient isolate is IL-4 dependent.