Prior characterization of M-LECP showed the following: (1) they are derived from BM myeloid precursors induced by CSF-1 [9,10], the main promoter of myeloid-macrophage lineage [12]; (2) acquisition of lymphatic phenotype in CSF-1-primed myeloid precursors is induced by TLR4 pathway activation [9]; (3) they are identified by a unique signature of co-expressed stem, myeloid, and LEC markers [9,10]; and (4) tumor-recruited M-LECP can be classified as tumor-associated macrophages (TAMs) as both populations share specific markers of immunosuppressive M2 type. This evidence concerns the gene TLR4 and neoplasm.