Human adipose stem/stromal cells induced to differentiate in co-cultures with the adrenocortical carcinoma cell line (H295R) showed lower levels of proteins normally associated with functional adipocytes, such as adiponectin, Fatty Acid-Binding Protein 4 (FABP4) and Hormone-Sensitive Lipase (HSL). The gene discussed is LIPE; the disease is adrenal cortex carcinoma.