Our previous study demonstrated that Sirtuin 3 deficiency that upregulated TIGAR in cardiomyocytes (Li et al., 2021) also sensitized Ang‐II‐induced renal fibrosis via promoting pericyte‐fibroblast transition, iron overload, and reactive oxygen species (ROS) (Feng et al., 2020). This evidence concerns the gene TIGAR and renal fibrosis.