TGFB1 and renal fibrosis: TGF‐β1 promotes renal fibrosis via activation of both canonical and non‐canonical signaling pathways to induce activation of myofibroblasts, EMT, and deposition of excessive of extracellular matrix (ECM) (Kalluri & Neilson, 2003; Kriz et al., 2011; Meng et al., 2016).