The elevated expression of SUR1 subunit of KATP channels in nigral dopaminergic neurons was regulated by the transcription factors FOXA1 and FOXA2 at the early stage of PD.The upregulated SUR1 promotes its transmembrane transport and then causes the membrane hyperpolarization, which may promote the occurrence of cluster discharges mediated by NMDA receptors and affect the activities of dopaminergic neurons. The gene discussed is FOXA2; the disease is Parkinson disease.