By secreting a large number of pro-inflammatory cytokines such as S100A8/S100A9, interleukin (IL) 1β (IL-1β), IL-6, and IL-8, it not only promotes the growth and proliferation of AML cells, but also induces chronic inflammation to create an immunosuppressive environment for AML cells [6]. The gene discussed is S100A9; the disease is acute myeloid leukemia.