CETP and type 2 diabetes mellitus: Biologic plausibility exists for the ability to prevent diabetes through CETP inhibition: Individuals with CETP polymorphisms that increase HDL-C have been shown to have lowered risk of T2DM and improved glycaemic status.15 Cellular and mechanistic studies also support a potential mechanistic link between CETP, HDL-C, and T2DM.16,17