SCN11A and multiple sclerosis: In addition to DRG neurons, Nav1.8/Nav1.9 have been colocalized with A-type FHFs within other neuronal populations, such as trigeminal ganglion neurons, myenteric neurons, magnocellular neurosecretory cells of the supraoptic nucleus, the outer layers of the substantia gelatinosa, and cerebellar neurons in animal models of multiple sclerosis (Craner et al., 2003; Vohra et al., 2006; Heanue and Pachnis, 2006; Huang et al., 2014; Osorio et al., 2014).