As described earlier, the expression of cyclin D1 and cyclin D3 decreased in a dose‐dependent manner with LCA treatment (Figures 2D, 4C and S4L,M), which are the target genes for β‐catenin regulation and play a key role in cell cycle transition from G1 phase to S phase.50, 51, 52. This evidence concerns the gene CCND3 and Leber congenital amaurosis.