In RCC, PVT1 has an oncogenic effect, and its expression levels are typically increased in the tumor, as shown by several independent works,18, 21, 22, 23, 24 also reviewed in Bohosova et al.25However, none of these works contains the ROC analysis that would determine the discriminant value of the test based on PVT1 expression. This evidence concerns the gene PVT1 and neoplasm.