In order to explore the spatial patterns of cortical tau tangles in different amyloidosis stages, we determined the cortical regions with significant tau elevation of different CSF/PET Aβ stages and investigated the region-wise and voxel-wise associations of tau PET images with CSF Aβ42/Aβ40, Aβ PET and CSF p-Tau/Aβ40 in early (CSF+/PET− and CSF−/PET+) and late (CSF+/PET+) amyloidosis stages. This evidence concerns the gene MAPT and amyloidosis.