In contrast, individuals with abnormal CSF Aβ42/Aβ40 and abnormal Aβ PET (CSF+/PET+) had significant tau elevations in all the Brank ROIs, and both lower CSF Aβ42/Aβ40 and higher Aβ PET were correlated with higher tau in entorhinal, BraakIII/ IV and BraakV/VI in late amyloidosis stage. The gene discussed is MAPT; the disease is amyloidosis.