Furthermore, Aβ pathology may play an initiating role in Alzheimer's disease onset, leading to subsequent tau increases6,33,34 or longitudinal tau changes.3,35–37 The BraakI–VI stages38 have been proposed to characterize the spatial patterns of cortical neurofibrillary tau tangles based on the autopsy data. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.