MAPT and Alzheimer disease: The Temporal-metaROI (entorhinal, amygdala, parahippocampal, fusiform, inferior temporal and middle temporal)44 composite regions have been commonly used to detect Alzheimer's-related tau deposition in human brain.3,55–60 However, our findings suggested that we may not be able to use Temporal-metaROI regions to capture the cortical tau increase in early amyloidosis stage among these individuals who have a PET-first Aβ pathway, implying different cortical regions should be selected to detect early tau increase in early Alzheimer's disease.