HLA-A and early-onset autosomal dominant Alzheimer disease: These genetic variants and brain regions were also reported to be associated with schizophrenia.16,61–63 Interestingly, insula is thought to play a role in brain-immune interaction.47,64 Loss of grey matter in insula was found to be associated with schizophrenia.65 HLA-A*03:01∼HLA-B*07:02 haplotype was found to be associated with Alzheimer’s disease.