Theresulting system has a targeted impact on HER2-overexpressing N87 cells andleads to their apoptosis [155].Subsequently, the targeted delivery mechanisms elaborated in the reviewedstudies [154, 155] were combined into the DNA tetrahedron-based system forthe delivery of FUdR to the cells of a tumor induced by the injection of BT474cells; this system slowed down tumor progression approximately 2.5-fold [156]. Here, ERBB2 is linked to neoplasm.