The key molecular events required for immunogenic cell death to take place havebeen identified(Fig. 1).The first event of the ICD cascade is the exposure ofa complex formed by two proteins, calreticulin and disulfide isomerase ERp57,on the surface of dying tumor cells [11].Both proteins are normally located in the ER lumen andare translocated to the cell surface within a few hours after stimulation withICD inducers. Here, CALR is linked to neoplasm.