In isolated CHD, many of the same genes that play a key role in syndromic CHD can also be found to be implicated, such as NOTCH1 (Adams-Oliver syndrome) [25], TBX5 (Holt-Oram syndrome) [26], and JAG1 (Alagille syndrome) [27]. The gene discussed is TBX5; the disease is Holt-Oram syndrome.