It is well known that the CHD phenotype among individuals with PTPN11 mutations differ from those with Noonan syndrome and LEOPARD syndrome, in that pulmonary stenosis is most common in Noonan syndrome [29, 30], whereas hypertrophic cardiomyopathy prevails in LEOPARD syndrome [31]. The gene discussed is PTPN11; the disease is hypertrophic cardiomyopathy.