To explore the molecular mechanisms that drive GRHL3 localization to the cytoplasm from the nucleus, we affinity-purified interaction partners of GRHL3 from MCF7 cells, a human cell line derived from breast adenocarcinoma, in which GRHL3 expression is observed in the nucleus and cytoplasm in THE HUMAN PROTEIN ATLAS (https://www.proteinatlas.org) (Fig. S1d–j). The gene discussed is GRHL3; the disease is breast adenocarcinoma.