Notably, in both cohorts, the highest positive correlation was with histone acetyltransferase 1 (HAT1) (LGG:ρ = 0.71, p = 1.00e–51; GBM:ρ = 0.31; p < 5.50e–05) and among the LGG, this correlation was significantly higher in anaplastic oligodendrogliomas (WHO grade 3) (ρ = 0.64, p = 1.7e−07) and in mixed glioma (WHO grade 3) (ρ = 0.62, p = 1.9e−05) (Fig. 6a), suggesting that GPX7 might be epigenetically regulated by HAT1-mediated acetylation, especially in high-grades. Here, HAT1 is linked to central nervous system cancer.