The results mentioned above, along with the strong association between GPX7 and several immunosuppressive cells (e.g., NKT cells, TAMs, and MDSCs) or inhibitory immune checkpoint markers (e.g., PD-1, CTLA-4, LAG-3, TIGIT, TIM-3 and CD96) further enhances the importance of GPX7 in the regulation of an immunosuppressive tumor microenvironment158–162. The gene discussed is TIGIT; the disease is neoplasm.