CD4 and glioma: Together with the extensive epigenetic reprogramming dictated by the glioma TME, the prominent association between GPX7 expression and CD4+ cell subtype signatures (e.g., Th1, Th2 and Treg) seen in our study suggests the role of GPX7 in CD4+ T cell polarization, which may participate in the lack of effective immune activation against gliomas156,157.