At the tumoral site, tumor-associated neutrophils (TANs) support glioma infiltration and progression, respectively, secreting elastase149 and neutrophil extracellular traps (NETs)150, which regulate the HMGB1/RAGE/IL-8 axis150, that ultimately leads to ROS generation, thus partially explaining, therefore, the upregulation of GPX7 associated with neutrophil infiltration seen in our study. Here, GPX7 is linked to central nervous system cancer.