Although GPX7 depletion is non-lethal, GPx7−/− mice carry multi-organ abnormalities (e.g. cardiomegaly, splenomegaly, glomerulonephritis and fatty liver) due to increased systemic oxidative stress damage, in addition to increased risk of carcinogenesis, severe oxidative DNA damage and reduced lifespan10. Here, GPX7 is linked to Splenomegaly.