At the tumoral site, tumor-associated neutrophils (TANs) support glioma infiltration and progression, respectively, secreting elastase149 and neutrophil extracellular traps (NETs)150, which regulate the HMGB1/RAGE/IL-8 axis150, that ultimately leads to ROS generation, thus partially explaining, therefore, the upregulation of GPX7 associated with neutrophil infiltration seen in our study. The gene discussed is HMGB1; the disease is central nervous system cancer.