CCL2 and central nervous system cancer: Additionally, our results align well with the involvement of CCL2/5, CCR2, and CXCR2/4 in regulating the TAN homing to glioma microenvironment, as we identified striking positive correlations of GPX7 with these chemokines/receptors151–153, thus revealing the potential role of GPX7 in the mobilization and recruitment of TANs through this pathway.