Notably, the negative impact of neutrophils, mDCs, CD4+ T cells and CAFs associated with increased GPX7 in LGG prognosis suggests that ROS-associated inflammation and immune cell infiltration in these cancers are associated with tumor progression rather than elimination, possibly due to immunosuppressive mechanisms operating in the TME, which might also be induced by oxidative stress. The gene discussed is GPX7; the disease is neoplasm.