GPX7 and esophageal adenocarcinoma: Our analysis established that DNA hypomethylation in the CpG islands and shores may be one of the mechanisms in leading to GPX7 overexpression in LGG, agreeing with Peng et al.21 and Chen et al.22, who also reported the same negative correlation when analyzing the promoter region of the GPX7 in esophageal adenocarcinomas and gastric cancer, respectively.