We identified striking positive correlations with most immune checkpoints and immune suppressive receptors in LGG, such as TIM3 (HAVCR2), IL10RB (interleukin 10 receptor subunit beta), LGALS9 (galectin 9), PDCD1LG2 (programmed cell death 1 ligand 2), TGFB1 (transforming growth factor beta 1) and TGFBR1 (transforming growth factor beta receptor 1). In contrast, only IL10RB was highly associated in GBM (Supplementary Fig. S9). The gene discussed is TGFB1; the disease is glioblastoma.