All insulin resistance markers were statistically higher in the group that used > 0.70 IU/kg compared to the low insulin use group, with a difference of 0.64 (95% CI: 0.54; 0.86), t(205) = 6.14, P-value =  < 0.001 for TG / HDL ratio, 0.55 (95% CI: 0.33; 0.77), t(205) = 4.97, P-value =  < 0.001 for TG and 0.52 (95% CI: 0.24; 0.80), t(2.13) = 3.64, p-value =  < 0.001. The gene discussed is INS; the disease is Insulin resistance.