We also quantified the levels of oxidative and ER stress markers in cross sections of the aortic sinus from Stk25 knockout and transgenic mice, and their wild-type littermates, where atherosclerosis was induced by gene transfer of gain-of-function mutant of PCSK9 (hPCSK9D374Y) combined with an atherogenic western-type diet20. Here, PCSK9 is linked to atherosclerosis.