We therefore tested our findings in organoids derived from three ER-positive invasive ductal breast carcinoma patients, a primary tumor, a bone metastasis harboring GATA3 frameshift mutations (primary: p.H433fs and metastasis: p.S410fs, Supplementary Fig. 5a) and one bone metastasis carrying wild-type GATA3 (Fig. 5a). Here, ESR1 is linked to invasive ductal breast carcinoma.