When tumours were segregated based on ERα status, ER-negative tumours (which encompass basal and most Her2+ breast cancers) demonstrated increased methylation (Fig. 2c), in agreement with our prior findings that LRIG1 is poorly expressed in Her2+ and basal breast tumours [19, 38], while richly expressed in ER-positive tumours [14]. Here, ERBB2 is linked to breast carcinoma.